Exhibit 31.01




I, Seth Lederman, certify that:


  1. I have reviewed this annual report on Form 10-K/A (Amendment No. 1) of Tonix Pharmaceuticals Holding Corp.;


  2. Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report;


Date: September 1, 2017  
Seth Lederman  
Chief Executive Officer