|
Ki
|
Serotonin, 5HT2A
|
|
Cyclobenzaprine
|
9.00E-09
|
|
Trazodone
|
6.30E-09
|
|
Doxepin
|
1.30E-08
|
|
Ki
|
Serotonin, 5HT2C
|
|
Cyclobenzaprine
|
>1E-5
|
|
Trazodone
|
>1E-5
|
|
Doxepin
|
7.50E-08
|
|
Ki
|
Histamine, H1
|
|
Cyclobenzaprine
|
>1E-5
|
|
Trazodone
|
>1E-5
|
|
Doxepin
|
8.80E-10
|
|
Targets
|
Cyclobenzaprine
|
|
Acetylcholinesterase
|
13.60%
|
|
Adenosine Transporter, solute carrier family 29
|
14.20%
|
|
Adenosine, A1
|
29.10%
|
|
Adenosine, A2a
|
14.40%
|
|
Adrenergic, Alpha 1A
|
120.60%
|
|
Adrenergic, Alpha 1B
|
109.20%
|
|
Adrenergic, Alpha 2A
|
99.00%
|
|
Adrenergic, Alpha 2B (subtype alpha2-C2 )
|
104.80%
|
|
Adrenergic, Alpha 2C
|
104.40%
|
|
Adrenergic, Beta 1
|
33.00%
|
|
Adrenergic, Beta 2
|
70.00%
|
|
Angiotensin II, AT1
|
4.00%
|
|
Bradykinin, BK2
|
23.30%
|
|
Calcium Channel, Type L (DHP Site)
|
43.80%
|
|
Calcium Channel, Type N
|
0.00%
|
|
Dopamine D1
|
100.70%
|
|
Dopamine Transporter
|
70.30%
|
|
Dopamine, D2s
|
98.90%
|
|
Dopamine, D3
|
101.90%
|
|
Dopamine, D4.4
|
95.30%
|
|
Dopamine, D5
|
91.70%
|
|
Endothelin, ET-A
|
0.00%
|
|
GABA A, Agonist Site
|
27.20%
|
|
GABA, Benzodiazepine, Central
|
0.00%
|
|
GABA, Chloride, TBOB Site
|
22.20%
|
|
GABA-B
|
10.20%
|
|
Glucocorticoid
|
18.40%
|
|
Glutamate, AMPA Site
|
20.80%
|
|
Glutamate, Kainate Site
|
20.80%
|
|
Glutamate, MK-801 Site
|
12.20%
|
|
Glutamate, NMDA Agonist Site
|
19.00%
|
|
Glutamate, NMDA, Glycine (Stry-insen.)
|
1.00%
|
|
Glutamate, NMDA, Phencyclidine Site
|
25.50%
|
|
Glycine, Strychnine-Sensitive
|
0.00%
|
|
Histamine, H1
|
18.80%
|
|
Histamine, H2
|
114.50%
|
|
Histamine, H3
|
12.20%
|
|
Kinase, Tyrosine, p60c-src
|
16.50%
|
|
Kinase,Tyrosine,b-Insulin Receptor (bIRK)
|
0.00%
|
|
Leukotriene, LTB4
|
5.50%
|
|
Leukotriene, LTD4
|
4.80%
|
|
Muscarinic, M1
|
101.60%
|
|
Muscarinic, M2
|
99.40%
|
|
Muscarinic, M3
|
99.50%
|
|
Muscarinic, M4
|
101.50%
|
|
Muscarinic, M5
|
100.10%
|
|
Neurokinin, NK1
|
23.60%
|
|
Neuropeptide, NPY2
|
0.00%
|
|
Nicotinic (a-bungarotoxin insensitive)
|
12.40%
|
|
Norepinephrine Transporter
|
91.70%
|
|
NOS (Neuronal-Binding)
|
24.30%
|
|
Opiate, Delta
|
0.00%
|
|
Opiate, Kappa
|
55.10%
|
|
Opiate, Mu
|
57.90%
|
|
Potassium Channel, ATP-Sensitive
|
17.50%
|
|
Potassium Channel, Ca2+ Act., VI
|
5.00%
|
|
Potassium Channel, Ca2+ Act., VS.
|
6.20%
|
|
Protease, Caspase 2
|
0.00%
|
|
Protease, Caspase 3
|
9.70%
|
|
Protein Phosphatase, PP1
|
14.20%
|
|
Protein Phosphatase, PP2C
|
19.10%
|
|
Protein Tyrosine Phosphatase, PTP1B
|
9.60%
|
|
Protein Tyrosine Phosphatase, PTP-B (Human)
|
0.00%
|
|
Serotonin Transporter
|
88.00%
|
|
Serotonin, 5HT1A
|
111.90%
|
|
Serotonin, 5HT1D
|
61.90%
|
|
Serotonin, 5HT2A
|
86.30%
|
|
Serotonin, 5HT2C
|
0.00%
|
|
Serotonin, 5HT3
|
99.10%
|
|
Serotonin, 5HT4
|
53.80%
|
|
Serotonin, 5HT5A
|
90.30%
|
|
Serotonin, 5HT6
|
94.40%
|
|
Serotonin, 5HT7
|
91.70%
|
|
Sigma 1
|
98.90%
|
|
Sigma 2
|
100.70%
|
|
Sodium Channel, Site 1
|
15.90%
|
|
Sodium Channel, Site 2
|
85.90%
|
|
Thromboxane, TXA2
|
24.70%
|