FORM 4
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940
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(Print or Type Responses)
1. Name and Address of Reporting Person *
MARIO ERNEST
   2. Issuer Name and Ticker or Trading Symbol
Tonix Pharmaceuticals Holding Corp. [TNXP] 		5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
__X__ Director _____ 10% Owner
_____ Officer (give title below) _____ Other (specify below)
(Last)
(First)
(Middle)
C/O TONIX PHARMACEUTICALS HOLDING CORP., 509 MADISON AVENUE, SUITE 306		 3. Date of Earliest Transaction (Month/Day/Year)
12/14/2017
(Street)

NEW YORK, NY 10022		 4. If Amendment, Date Original Filed(Month/Day/Year)
 6. Individual or Joint/Group Filing(Check Applicable Line)
_X_ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3)		 2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code
(Instr. 8)		 4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)		 5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4)		 6. Ownership Form: Direct (D) or Indirect (I)
(Instr. 4)		 7. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V Amount (A) or (D) Price
Common Stock, $0.001 par value 12/14/2017   S   1,967 D $ 3.58 (1) (2) 55,467 I By Ernest and Mildred Mario Revocable Trust
Common Stock, $0.001 par value 12/15/2017   S   5,000 D $ 3.55 (1) (3) 53,500 I By Ernest and Mildred Mario Revocable Trust
Common Stock, $0.001 par value 12/18/2017   S   10,000 D $ 3.57 (1) (4) 43,500 I By Ernest and Mildred Mario Revocable Trust
Common Stock, $0.001 par value 12/19/2017   S   6,035 D $ 3.51 (1) (5) 37,465 I By Ernest and Mildred Mario Revocable Trust
Common Stock, $0.001 par value 12/20/2017   S   8,965 D $ 3.44 (1) (6) 28,500 I By Ernest and Mildred Mario Revocable Trust
Common Stock, $0.001 par value 12/21/2017   S   5,000 D $ 3.46 (1) (7) 23,500 I By Ernest and Mildred Mario Revocable Trust
Common Stock, $0.001 par value               10,000 D  

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
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Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 3)		 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year) 3A. Deemed Execution Date, if any (Month/Day/Year) 4. Transaction Code
(Instr. 8)		 5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4, and 5)		 6. Date Exercisable and Expiration Date
(Month/Day/Year)		 7. Title and Amount of Underlying Securities
(Instr. 3 and 4)		 8. Price of Derivative Security
(Instr. 5)		 9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 4)		 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 4)		 11. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares

Reporting Owners

Reporting Owner Name / Address Relationships
 Director  10% Owner  Officer  Other
MARIO ERNEST
C/O TONIX PHARMACEUTICALS HOLDING CORP.
509 MADISON AVENUE, SUITE 306
NEW YORK, NY 10022		   X      

Signatures

 /s/ Jessica Morris, Attorney-in-Fact   12/22/2017
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) The volume weighted average purchase price of common stock sold by the reporting person in open market transactions on the transaction date. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each price.
(2) The range of sale prices on the transaction date was $3.530 to $3.610 per share.
(3) The range of sale prices on the transaction date was $3.520 to $3.650 per share.
(4) The range of sale prices on the transaction date was $3.510 to $3.605 per share.
(5) The range of sale prices on the transaction date was $3.458 to $3.571 per share.
(6) The range of sale prices on the transaction date was $3.400 to $3.510 per share.
(7) The range of sale prices on the transaction date was $3.410 to $3.500 per share.

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