NOTE 8 – COMMITMENTS

Research and development contracts

The Company has entered into contracts with various contract research organizations with outstanding commitments aggregating approximately $10.1 million at June 30, 2018 for future work to be performed. Following the orderly closing of the HONOR study, the Company expects its outstanding commitments to decrease in the near term.

Operating leases

As of June 30, 2018, future minimum lease payments were as follows (in thousands):

Defined contribution plan

The Company has a qualified defined contribution plan (the “401(k) Plan”) pursuant to Section 401(k) of the Code, whereby all eligible employees may participate. Participants may elect to defer a percentage of their annual pretax compensation to the 401(k) Plan, subject to defined limitations. The Company is required to make contributions to the 401(k) Plan equal to 100 percent of each participant’s pretax contributions of up to six percent of his or her eligible compensation, and the Company is also required to make a contribution equal to six percent of each participant’s salary, on an annual basis, subject to limitations under the Code. The Company charged operations $31,000 and $62,000 for the three and six months ended June 30, 2018, respectively, and $16,000 and $32,000 for the three and six months ended June 30, 2017, respectively, for contributions under the 401(k) Plan.