Annual report pursuant to Section 13 and 15(d)

CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY

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CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY - USD ($)
$ in Thousands
Series A Convertible Preferred Stock [Member]
Common Stock [Member]
Additional Paid in Capital [Member]
Accumulated Other Comprehensive loss [Member]
Accumulated Deficit [Member]
Total
Balance, at beginning at Dec. 31, 2016   $ 1 $ 166,607 $ (7) $ (141,240) $ 25,361
Balance, at beginning (in shares) at Dec. 31, 2016   394,787        
Increase (Decrease) in Stockholders' Equity [Roll Forward]            
Employee stock purchase plan     74     74
Employee stock purchase plan (in shares)   2,026        
Issuance of common stock related to restricted stock units (in shares)   1,050        
Issuance of common stock in February 2017 ($50.90 per share), March 2017 ($45.00 per share) and April 2017 ($65.50 per share), net of transaction expenses of $280     9,062     9,062
Issuance of common stock in February 2017 ($50.90 per share), March 2017 ($45.00 per share) and April 2017 ($65.50 per share), net of transaction expenses of $280 (in shares)   148,648        
Issuance of common stock in April 2017 ($44.50 per share, net of transaction expenses of $888)     8,325     8,325
Issuance of common stock in April 2017 ($44.50 per share, net of transaction expenses of $888) (in shares)   207,000        
Issuance of commitment shares in September 2017 ($41.10 per share)          
Issuance of commitment shares in September 2017 ($41.10 per share) (in shares)   7,304        
Issuance of common stock in exchange for exercise of warrants in April 2017 ($63.00 per share)     14     14
Issuance of common stock in exchange for exercise of warrants in April 2017 ($63.00 per share) (in shares)   225        
Issuance of common stock in October 2017 ($45.60 per share, net of transaction expenses of $15)     1,118     1,118
Issuance of common stock in October 2017 ($45.60 per share, net of transaction expenses of $15) (in shares)   24,834        
Stock-based compensation     1,790     1,790
Foreign currency translation loss       (5)   (5)
Net loss         (21,123) (21,123)
Balance, at end at Dec. 31, 2017   $ 1 186,990 (12) (162,363) 24,616
Balance, at end (in shares) at Dec. 31, 2017   785,874        
Increase (Decrease) in Stockholders' Equity [Roll Forward]            
Issuance of common stock related to restricted stock units (in shares)   75        
Issuance of commitment shares in September 2017 ($41.10 per share) (in shares)   35,000        
Issuance of common stock in October 2017 ($45.60 per share, net of transaction expenses of $15)     2,315     2,315
Issuance of common stock in October 2017 ($45.60 per share, net of transaction expenses of $15) (in shares)   117,961        
Issuance of common stock under At-the-market offering, net of transactional expenses of $212   $ 1 6,856     6,857
Issuance of common stock under At-the-market offering, net of transactional expenses of $212 (in shares)   593,350        
Issuance of Series A Convertible preferred stock and common stock warrants in December 2018 ($1,000.00 per unit, net of transactional expenses of $1,159)     10,825     10,825
Issuance of Series A Convertible preferred stock and common stock warrants in December 2018 ($1,000.00 per unit, net of transactional expenses of $1,159) (in shares) 11,984          
Issuance of common stock and common stock warrants in December 2018 ($3.50 per unit, net of transaction expenses of $353)   $ 1 3,541     3,542
Issuance of common stock and common stock warrants in December 2018 ($3.50 per unit, net of transaction expenses of $353) (in shares)   1,111,710        
Beneficial conversion feature in connection with issuance of Series A Convertible preferred stock     3,266     3,266
Preferred stock deemed dividend     (3,266)     (3,266)
Issuance of common stock upon conversion of Series A Convertible preferred stock (in shares) (2,128) 608,000        
Stock-based compensation     1,627     1,627
Foreign currency translation loss       (29)   (29)
Net loss         (26,089) (26,089)
Balance, at end at Dec. 31, 2018   $ 3 $ 212,154 $ (41) $ (188,452) $ 23,664
Balance, at end (in shares) at Dec. 31, 2018 9,856 3,251,970