Quarterly report pursuant to Section 13 or 15(d)

STOCK-BASED COMPENSATION (Details Narrative)

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STOCK-BASED COMPENSATION (Details Narrative) - USD ($)
$ / shares in Units, $ in Thousands
1 Months Ended 3 Months Ended
Dec. 31, 2017
Mar. 01, 2017
May 11, 2016
Feb. 09, 2016
Jun. 09, 2014
Feb. 28, 2017
Jan. 31, 2017
Apr. 30, 2012
Mar. 31, 2017
Mar. 31, 2016
Number of shares granted other than option                 5,625  
Stock-based compensation expense                 $ 567 $ 896
Number of shares granted options to purchase                 90,000  
Exercise price (in dollars price per share)                 $ 5.50  
Exercisable, weighted average remaining contractual term                 7 years 1 month 10 days  
Stock Option [Member]                    
Stock-based compensation expense                 $ 500 $ 800
Unrecognized compensation cost                 $ 1,600  
Unrecognized weighted average period                 1 year 4 months 20 days  
Stock Option [Member] | Exercise Price @$98.70 [Member]                    
Options cancelled                   108,541
Exercise prices of forfeited shares (in dollars per share)                   $ 98.70
Stock Option [Member] | Exercise Price @$66.80 [Member]                    
Options cancelled                   108,541
Exercise prices of forfeited shares (in dollars per share)                   $ 66.80
Stock Option [Member] | Exercise Price @59.50 [Member]                    
Options cancelled                   1,320
Exercise prices of forfeited shares (in dollars per share)                   $ 59.50
Restricted Stock Units [Member]                    
Number of shares granted other than option                  
Stock-based compensation expense                 $ 50 $ 79
Unrecognized compensation cost                 $ 21,000  
Unrecognized weighted average period                 2 months  
Employee [Member]                    
Vesting period       1 year            
Weighted average grant date fair value other than option (in dollars per share)   $ 3.36   $ 24.91            
Description of award vesting rights  

Vesting 1/3 on the first anniversary and 1/36th each month thereafter for 24 months.

               
Number of shares granted options to purchase   61,750   40,300            
Exercise price (in dollars price per share)   $ 5.50   $ 50.30            
Exercisable, weighted average remaining contractual term   10 years   10 years            
Employee [Member] | Common Stock [Member]                    
Description of award vesting rights      

Vesting 1/3 each upon the Company’s common stock having an average closing sale price equal to or exceeding each of $60.00, $70.00 and $80.00 per share for 20 consecutive trading days, subject to a one year minimum service period prior to vesting.

           
Number of shares granted options to purchase       20,000            
Exercise price (in dollars price per share)       $ 50.30            
Exercisable, weighted average remaining contractual term       10 years            
Employee [Member] | Subsequent Event [Member]                    
Description of award vesting rights

Vesting 50% upon achieving enrollment of 250 participants in the ongoing HONOR study by December 31, 2017, and the remaining 50% vesting 1% for each participant that is enrolled in the HONOR study by December 31, 2017 in excess of 250, subject to a one year minimum service period prior to vesting.

                 
Number of shares granted options to purchase 28,250                  
Exercise price (in dollars price per share) $ 5.50                  
Exercisable, weighted average remaining contractual term 10 years                  
Employee [Member] | Subsequent Event [Member] | Minimum [Member]                    
Vesting period 1 year                  
2012 Incentive Stock Option Plan [Member]                    
Number of shares authorized               55,000    
Description of award vesting rights              

Stock options granted pursuant to the Plans typically vest 1/3rd 12 months from the date of grant and 1/36th each month thereafter for 24 months and expire ten years from the date of grant. In addition, the Company also issues performance-based options to executive officers, which options vest when the target parameters are met, subject to a one year minimum service period prior to vesting.

   
2014 Incentive Stock Option Plan [Member]                    
Number of shares authorized         180,000          
Description of award vesting rights        

Stock options granted pursuant to the Plans typically vest 1/3rd 12 months from the date of grant and 1/36th each month thereafter for 24 months and expire ten years from the date of grant. In addition, the Company also issues performance-based options to executive officers, which options vest when the target parameters are met, subject to a one year minimum service period prior to vesting.

         
2014 Incentive Stock Option Plan [Member] | Non-Employees Directors [Member] | Restricted Stock Units [Member]                    
Vesting period           1 year        
Number of shares granted other than option           5,625        
Weighted average grant date fair value other than option (in dollars per share)           $ 38.10        
2016 Incentive Stock Option Plan [Member]                    
Number of shares authorized     278,500              
Description of terms of exercise price    

The exercise price of an incentive stock option may not be less than 110% of fair value of the common stock at the date of the grant for a 10% or more shareholder and 100% of fair value for a grantee who is not a 10% shareholder.

             
Vesting period     5 years              
Expiration period     10 years              
Number of shares reserved for future issuance     278,500           122,596  
Maximum number of shares issued pursuant to stock-settled awards     75,000              
Description of award under stock incentive plan    

(i) be granted options or SARs with respect to more than 75,000 shares of the Company’s common stock, (ii) earn more than 50,000 shares of the Company’s common stock under restricted stock awards, restricted stock unit awards, performance awards and/or other share-based awards, or (iii) earn more than $5,000,000 under an award; provided, however, that each of these limitations shall be multiplied by two

             
Description of stock-settled awards    

The calculation shall be based on one share for every one share that was subject to an option or SAR and 1.25 shares for every one share that was subject to an award other than an option or SAR.

             
Description of award vesting rights    

Stock options granted pursuant to the Plans typically vest 1/3rd 12 months from the date of grant and 1/36th each month thereafter for 24 months and expire ten years from the date of grant. In addition, the Company also issues performance-based options to executive officers, which options vest when the target parameters are met, subject to a one year minimum service period prior to vesting.

             
2014 Employee Stock Purchase Plan [Member]                    
Number of shares authorized         30,000          
Number of shares reserved for future issuance                 19,449  
Stock-based compensation expense                 $ 36 $ 59
Employee payroll deductions             $ 10,000   $ 42  
Number of shares issued under ESPP             2,496