Annual report pursuant to Section 13 and 15(d)

CONSOLIDATED STATEMENT OF STOCKHOLDERS' EQUITY

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CONSOLIDATED STATEMENT OF STOCKHOLDERS' EQUITY - USD ($)
$ in Thousands
Total
Preferred stock [Member]
Common stock [Member]
Additional Paid in Capital [Member]
Accumulated Other Comprehensive Gain (loss) [Member]
Accumulated Deficit [Member]
Balance at Dec. 31, 2012 $ 959 $ 0 $ 2 $ 16,801 $ 0 $ (15,844)
Balance (in shares) at Dec. 31, 2012   0 2,159,159      
Stock-based compensation 1,717 $ 0 $ 0 1,717 0 0
Issuance of common stock and warrants, net of transaction expenses 10,042 $ 0 $ 3 10,039 0 0
Issuance of common stock and warrants, net of transaction expenses (in shares)   0 2,680,000      
Issuance of common stock in exchange for exercise of warrants 307 $ 0 $ 0 307 0 0
Issuance of common stock in exchange for exercise of warrants (in shares)   0 38,334      
Issuance of common stock in exchange for exercise of warrants in December 2013 ($4.25 per share) 3,761 $ 0 $ 1 3,760 0 0
Issuance of common stock in exchange for exercise of warrants in December 2013 ($4.25 per share) (in shares)   0 884,885      
Issuance of common stock in exchange for exercise of warrants in December 2013 ($8.00 per share) 560 $ 0 $ 0 560 0 0
Issuance of common stock in exchange for exercise of warrants in December 2013 ($8.00 per share) (in shares)   0 70,031      
Issuance of common stock in exchange for warrants exercised on a cashless basis 0 $ 0 $ 0 0 0 0
Issuance of common stock in exchange for warrants exercised on a cashless basis (in shares)   0 1,672      
Warrants issued for services rendered 51 $ 0 $ 0 51 0 0
Foreign currency translation adjustment (1) 0 0 0 (1) 0
Net loss (10,884) 0 0 0 0 (10,884)
Balance at Dec. 31, 2013 6,512 $ 0 $ 6 33,235 (1) (26,728)
Balance (in shares) at Dec. 31, 2013   0 5,834,081      
Stock-based compensation 3,053 $ 0 $ 0 3,053 0 0
Issuance of common stock net of transaction expenses 40,654 $ 0 $ 3 40,651 0 0
Issuance of common stock net of transaction expenses of (in shares)   0 2,898,550      
Issuance of common stock and warrants, net of transaction expenses 7,182 $ 0 $ 1 7,181    
Issuance of common stock and warrants, net of transaction expenses (in shares)   0 657,000      
Issuance of common stock in exchange for exercise of warrants 5,661 $ 0 $ 1 5,660 0 0
Issuance of common stock in exchange for exercise of warrants (in shares)   0 1,331,911      
Issuance of common stock to acquire intellectual property rights from related party in March 2014 ($12.15 per share)   0 50,000      
Issuance of common stock to acquire intellectual property rights from related party in March 2014 ($12.15 per share) (in shares) 608 $ 0 $ 0 608   0
Issuance of common stock in exchange for warrants exercised on a cashless basis 0 $ 0 $ 0 0 0 0
Issuance of common stock in exchange for warrants exercised on a cashless basis (in shares)   0 33,678      
Foreign currency translation adjustment 3 $ 0 $ 0 0 3 0
Employee stock purchase plan 35 $ 0 $ 0 35 0 0
Employee stock purchase plan (in shares)   0 0      
Net loss (27,616) $ 0 $ 0 0 0 (27,616)
Balance at Dec. 31, 2014 36,092 $ 0 $ 11 90,423 2 (54,344)
Balance (in shares) at Dec. 31, 2014   0 10,805,220      
Stock-based compensation 4,389 $ 0   4,389 0 0
Issuance of common stock net of transaction expenses 29,000 $ 0 $ 5 28,995 0 0
Issuance of common stock net of transaction expenses of (in shares)   0 5,318,700      
Issuance of common stock and warrants, net of transaction expenses 18,685 $ 0 $ 3 18,682    
Issuance of common stock and warrants, net of transaction expenses (in shares)   0 2,673,750      
Issuance of common stock in exchange for exercise of warrants 9 $ 0 $ 0 9 0 0
Issuance of common stock in exchange for exercise of warrants (in shares)   0 2,000      
Foreign currency translation adjustment 8 $ 0 $ 0 0 8 0
Employee stock purchase plan 160 $ 0 $ 0 160 0 0
Employee stock purchase plan (in shares)   0 31,999      
Unrealized gain on available for sale, net of tax (27)       (27)  
Net loss (48,054) $ 0 $ 0 0 0 (48,054)
Balance at Dec. 31, 2015 $ 40,262 $ 0 $ 19 $ 142,658 $ (17) $ (102,398)
Balance (in shares) at Dec. 31, 2015   0 18,831,669