Annual report pursuant to Section 13 and 15(d)

CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY

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CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY - USD ($)
$ in Thousands
Preferred stock [Member]
Common stock [Member]
Additional Paid in Capital [Member]
Accumulated Other Comprehensive Gain (loss) [Member]
Accumulated Deficit [Member]
Total
Balance, at beginning at Dec. 31, 2014 $ 1 $ 90,433 $ 2 $ (54,344) $ 36,092
Balance, at beginning (in shares) at Dec. 31, 2014 1,080,522        
Increase (Decrease) in Stockholders' Equity [Roll Forward]            
Issuance of common stock in February 2015 ($58.50 per share) net of transaction expenses of $2,115   $ 1 28,999     29,000
Issuance of common stock in February 2015 ($58.50 per share) net of transaction expenses of $2,115 (in shares)   531,870        
Issuance of common stock in July 2015 ($75.00 per share), net of transaction expenses of $1,369     18,685     18,685
Issuance of common stock in July 2015 ($75.00 per share), net of transaction expenses of $1,369 (in shares)   267,375        
Issuance of common stock in exchange for exercise of warrants ($42.50 per share)     9     9
Issuance of common stock in exchange for exercise of warrants ($42.50 per share) (in shares)   200        
Employee stock purchase plan       160   160
Employee stock purchase plan (in shares)   3,200        
Stock-based compensation     4,389     4,389
Foreign currency translation loss       8   8
Unrealized gain/(loss) on available for sale securities       (27)   (27)
Net loss         (48,054) (48,054)
Balance, at end at Dec. 31, 2015 $ 2 142,675 (17) (102,398) 40,262
Balance, at end (in shares) at Dec. 31, 2015 1,883,167        
Increase (Decrease) in Stockholders' Equity [Roll Forward]            
Issuance of common stock related to restricted stock units (in shares)   4,200        
Employee stock purchase plan     167     167
Employee stock purchase plan (in shares)   4,855        
Issuance of common stock in May and June 2016 ($24.00 per share), September 2016 ($7.40 per share), and October 2016 ($6.50 per share), net of transaction expenses of $280     5,377     5,377
Issuance of common stock in May and June 2016 ($24.00 per share), September 2016 ($7.40 per share), and October 2016 ($6.50 per share), net of transaction expenses of $280 (in shares)   500,889        
Issuance of common stock in June 2016 ($20.00 per share), net of transaction expenses of $916   $ 1 9,083     9,084
Issuance of common stock in June 2016 ($20.00 per share), net of transaction expenses of $916 (in shares)   500,000        
Issuance of common stock in July 2016 ($20.00 per share), net of transaction expenses of $105     1,395     1,395
Issuance of common stock in July 2016 ($20.00 per share), net of transaction expenses of $105 (in shares)   75,000        
Issuance of common stock in October 2016 ($5.50 per share), net of transaction costs of $585   $ 1 4,641     4,642
Issuance of common stock in October 2016 ($5.50 per share), net of transaction costs of $585 (in shares)   950,000        
Stock-based compensation     3,266     3,266
Foreign currency translation loss       (17)   (17)
Unrealized gain/(loss) on available for sale securities       27   27
Net loss         (38,842) (38,842)
Balance, at end at Dec. 31, 2016 $ 4 $ 166,604 $ (7) $ (141,240) $ 25,361
Balance, at end (in shares) at Dec. 31, 2016 3,918,111