Tonix Pharmaceuticals Holding Corp. Annual report pursuant to Section 13 and 15(d)

Annual report pursuant to Section 13 and 15(d)

SALE OF COMMON STOCK (Details Narrative)

SALE OF COMMON STOCK (Details Narrative) - USD ($)																1 Months Ended		2 Months Ended		3 Months Ended	12 Months Ended
SALE OF COMMON STOCK (Details Narrative) - USD ($)	Dec. 03, 2021	May 14, 2021	Feb. 09, 2021	Feb. 08, 2021	Jan. 11, 2021	Sep. 03, 2020	Jul. 13, 2020	Apr. 08, 2020	Mar. 03, 2020	Feb. 28, 2020	Feb. 11, 2020	Feb. 07, 2020	Jan. 16, 2020	Nov. 14, 2019	Aug. 20, 2019	Aug. 31, 2020	Feb. 29, 2020	Mar. 14, 2022	Mar. 31, 2020	Mar. 31, 2021	Dec. 31, 2021	Dec. 31, 2020
Class of Stock [Line Items]
Preferred stock deemed dividend																						$ 1,260,000
Proceeds from exercise of warrants																					2,000	9,896,000
Warrants deemed dividend																						$ 451,000
Warrants from Feb 2020 Financing [Member]
Class of Stock [Line Items]
Exercise price (in dollars per share)																$ 0.57			$ 0.57		$ 0.57	$ 0.57
Number of exercised warrants																2,200,000			10,800,000		3,400	13,000,000
Proceeds from exercise of warrants																$ 1,300,000			$ 6,200,000		$ 2,000	$ 7,500,000
Warrants from Nov 2019 Financing [Member]
Class of Stock [Line Items]
Exercise price (in dollars per share)																			$ 0.57			$ 0.57
Number of exercised warrants																			2,300,000			2,300,000
Proceeds from exercise of warrants																			$ 1,300,000			$ 1,300,000
Warrants deemed dividend																	$ 500,000
Series B Preferred Stock [Member]
Class of Stock [Line Items]
Number of shares converted (in shares)																				5,313
Purchase Agreement With Lincoln Park [Member] \| Subsequent Event [Member]
Class of Stock [Line Items]
Number of shares issued (in shares)																		22,000,000
Proceeds from equity offerings																		$ 4,500,000
Purchase Agreement With Lincoln Park [Member] \| Lincoln Park Capital Fund, LLC [Member]
Class of Stock [Line Items]
Commitment to purchase shares under agreement	$ 80,000,000
Number of shares issued (in shares)	2,909,091
Number of shares issued, value	$ 1,600,000
Purchase Agreement 2021 [Member]
Class of Stock [Line Items]
Number of shares issued (in shares)																					64,500,000
Proceeds from equity offerings																					$ 41,300,000
Percentage of issuance by an issuer of common stock																					19.99%
Purchase Agreement 2021 [Member] \| Lincoln Park Capital Fund, LLC [Member]
Class of Stock [Line Items]
Commitment to purchase shares under agreement		$ 80,000,000													$ 15,000,000
Number of shares issued (in shares)		1,280,000
Number of shares issued, value		$ 1,600,000													$ 200,000
Underwriting Agreement [Member] \| Common Class A [Member]
Class of Stock [Line Items]
Sale of stock, price (in dollars per share)												$ 0.57
Number of shares sold												3,837,000
Underwriting Agreement [Member] \| Common Class B [Member]
Class of Stock [Line Items]
Sale of stock, price (in dollars per share)												$ 1,000
Number of shares sold												5,313
Conversion price (in dollars per share)												$ 0.57
Number of shares of common stock convertible												1,754.386
Number of warrants issued												1,754.386
Exercise price (in dollars per share)												$ 0.57
Warrant term												5 years
Underwriting Agreement [Member] \| Alliance Global Partners [Member]
Class of Stock [Line Items]
Number of shares issued (in shares)				58,333,334	50,000,000		20,940,000			14,550,000
Proceeds from equity offerings			$ 65,000,000		$ 36,900,000		$ 9,600,000		$ 14,800,000
Sale of stock, price (in dollars per share)				$ 1.20	$ 0.80		$ 0.50			$ 1.10
Cash fee			7.00%		7.00%
Underwriting discount			$ 4,900,000		$ 2,800,000		$ 700,000		1,100,000
Expenses from sale of stock			$ 100,000		$ 300,000		$ 100,000		$ 100,000
Discount percentage							7.00%		7.00%
Underwriting Agreement [Member] \| Alliance Global Partners [Member] \| Class A Units [Member]
Class of Stock [Line Items]
Number of shares issued (in shares)														547,420
Underwriting Agreement [Member] \| Alliance Global Partners [Member] \| Class B Units [Member]
Class of Stock [Line Items]
Number of shares issued (in shares)														7,938
Sale of stock, price (in dollars per share)														$ 1,000
Underwriting Agreement [Member] \| Alliance Global Partners [Member] \| Class A Units [Member]
Class of Stock [Line Items]
Sale of stock, price (in dollars per share)														1.94
Underwriting Agreement [Member] \| Alliance Global Partners [Member] \| Warrants [Member] \| Class B Units [Member]
Class of Stock [Line Items]
Exercise price (in dollars per share)														$ 1.94
Warrant term														5 years
Number of warrants to purchase to common stock per unit														515.464
Underwriting Agreement [Member] \| Alliance Global Partners [Member] \| Common Warrants [Member]
Class of Stock [Line Items]
Value of securities traded to trigger exercise of warrants														$ 9,000,000
Underwriting Agreement [Member] \| Alliance Global Partners [Member] \| Common Warrants [Member] \| Class B Units [Member]
Class of Stock [Line Items]
Exercise price (in dollars per share)														$ 1.94
Warrant term														12 months
Number of warrants to purchase to common stock per unit														257.732
Underwriting Agreement [Member] \| Alliance Global Partners [Member] \| Common Class A And Class B [Member]
Class of Stock [Line Items]
Proceeds from equity offerings												$ 6,500,000
Underwriting discount												500,000
Expenses from sale of stock												$ 500,000
Discount percentage												7.00%
Underwriting Agreement [Member] \| Alliance Global Partners [Member] \| Series B Preferred Stock [Member]
Class of Stock [Line Items]
Preferred stock deemed dividend											$ 1,300,000
Underwriting Agreement [Member] \| Alliance Global Partners [Member] \| Series A Preferred Stock [Member] \| Class B Units [Member]
Class of Stock [Line Items]
Conversion price (in dollars per share)														$ 1.94
Number of shares of common stock convertible														515.464
Sales Agreement [Member] \| Alliance Global Partners [Member]
Class of Stock [Line Items]
Offering price per agreement								$ 240,000,000
Commission to agent								3.00%
Sales Agreement [Member] \| Subsequent Event [Member]
Class of Stock [Line Items]
Number of shares issued (in shares)																		15,600,000
Sales Agreement [Member] \| Alliance Global Partners [Member]
Class of Stock [Line Items]
Proceeds from equity offerings																					$ 69,300,000
Number of shares sold																					110,200,000
Sales Agreement [Member] \| Alliance Global Partners [Member] \| Subsequent Event [Member]
Class of Stock [Line Items]
Number of shares issued (in shares)																		15,600,000
Proceeds from equity offerings																		$ 4,300,000
Purchase Agreement 2020 [Member]
Class of Stock [Line Items]
Number of shares issued (in shares)																						25,400,000
Proceeds from equity offerings																						$ 14,600,000
Percentage of issuance by an issuer of common stock																						19.99%
Number of shares sold																						26,000,000
Purchase Agreement 2020 [Member] \| Lincoln Park Capital Fund, LLC [Member]
Class of Stock [Line Items]
Commitment to purchase shares under agreement						$ 30,000,000
Number of shares issued (in shares)						600,000
Number of shares issued, value						$ 498,000
Purchase Agreement 2019 [Member]
Class of Stock [Line Items]
Number of shares issued (in shares)																						464,471
Proceeds from equity offerings																						$ 300,000
Percentage of issuance by an issuer of common stock													19.90%
Purchase Agreement 2019 [Member] \| Lincoln Park Capital Fund, LLC [Member]
Class of Stock [Line Items]
Number of shares issued (in shares)															35,529