Annual report pursuant to Section 13 and 15(d)

CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY

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CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY - USD ($)
$ in Thousands
Common stock [Member]
Additional Paid-in Capital [Member]
Accumulated Other Comprehensive Gain (loss) [Member]
Accumulated Deficit [Member]
Total
Balance, at beginning at Dec. 31, 2015 $ 2 $ 142,675 $ (17) $ (102,398) $ 40,262
Balance, at beginning (in shares) at Dec. 31, 2015 1,884,237        
Increase (Decrease) in Stockholders' Equity [Roll Forward]          
Employee stock purchase plan   167     167
Employee stock purchase plan (in shares) 4,855        
Issuance of common stock related to restricted stock units (in shares) 4,200        
Issuance of common stock in October 2017 and 2016 ($4.56 and 5.50 per share, net of transaction expenses of $15 and 585) $ 1 4,641     4,642
Issuance of common stock in October 2017 and 2016 ($4.56 and 5.50 per share, net of transaction expenses of $15 and 585) (in shares) 950,000        
Issuance of common stock in May and June 2016 ($24.00 per share), September 2016 ($7.40 per share), and October 2016 ($6.50 per share) net of transaction expenses of $280   5,377     5,377
Issuance of common stock in May and June 2016 ($24.00 per share), September 2016 ($7.40 per share), and October 2016 ($6.50 per share) net of transaction expenses of $280 (in shares) 500,889        
Issuance of common stock in June 2016 ($20.00 per share), net of transaction expenses of $916 $ 1 9,083     9,084
Issuance of common stock in June 2016 ($20.00 per share), net of transaction expenses of $916 (in shares) 500,000        
Issuance of common stock in July 2016 ($20.00 per share, net of transaction expenses of $105   1,395     1,395
Issuance of common stock in July 2016 ($20.00 per share, net of transaction expenses of $105 (in shares) 75,000        
Stock-based compensation   3,266     3,266
Foreign currency translation loss     (17)   (17)
Unrealized gain on available for sale securities     27   27
Net loss       (38,842) (38,842)
Balance, at end at Dec. 31, 2016 $ 4 166,604 (7) (141,240) 25,361
Balance, at end (in shares) at Dec. 31, 2016 3,919,181        
Increase (Decrease) in Stockholders' Equity [Roll Forward]          
Employee stock purchase plan   74     74
Employee stock purchase plan (in shares) 20,256        
Issuance of common stock related to restricted stock units        
Issuance of common stock related to restricted stock units (in shares) 10,500        
Issuance of common stock in February 2017 ($5.09 per share), March 2017 ($4.50 per share) and April 2017 ($6.55 per share), net of transaction expenses of $280 $ 2 9,060     9,062
Issuance of common stock in February 2017 ($5.09 per share), March 2017 ($4.50 per share) and April 2017 ($6.55 per share), net of transaction expenses of $280 (in shares) 1,486,474        
Issuance of common stock in April 2017 ($4.45 per share), net of transaction expenses of $888 $ 2 8,323     8,325
Issuance of common stock in April 2017 ($4.45 per share), net of transaction expenses of $888 (in shares) 2,070,000        
Issuance of commitment shares in September 2017 ($4.11 per share)      
Issuance of commitment shares in September 2017 ($4.11 per share) (in shares) 73,039        
Issuance of common stock in exchange for exercise of warrants in April 2017 ($6.30 per share) 14     14
Issuance of common stock in exchange for exercise of warrants in April 2017 ($6.30 per share) (in shares) 2,250        
Issuance of common stock in October 2017 and 2016 ($4.56 and 5.50 per share, net of transaction expenses of $15 and 585)   1,118     1,118
Issuance of common stock in October 2017 and 2016 ($4.56 and 5.50 per share, net of transaction expenses of $15 and 585) (in shares) 248,340        
Stock-based compensation   1,790     1,790
Foreign currency translation loss     (5)   (5)
Unrealized gain on available for sale securities        
Net loss       (21,123) (21,123)
Balance, at end at Dec. 31, 2017 $ 8 $ 186,983 $ (12) $ (162,363) $ 24,616
Balance, at end (in shares) at Dec. 31, 2017 7,830,040